Bicara Therapeutics Cash Position Down to $462.1M

By Philip Seaworth • Tuesday, May 13 15:24 • Permanent Link

Bicara Therapeutics Inc. (NASDAQ: BCAX) has reported its financial results for the first quarter ended March 31, 2025. The company's cash position stood at $462.1 million, down from $489.7 million as of December 31, 2024. Research and development expenses were $34.3 million for the first quarter of 2025, compared to $12.0 million for the first quarter of 2024. General and administrative expenses were $7.5 million for the first quarter of 2025, an increase from $3.3 million for the first quarter of 2024. The net loss totaled $36.8 million for the first quarter of 2025, compared to $12.5 million for the first quarter of 2024.

Bicara Therapeutics is advancing its pivotal phase 2/3 trial of ficerafusp alfa in 1L recurrent/metastatic (r/m) head and neck squamous cell carcinoma (HNSCC). The company is expecting to present updated data from the ongoing phase 1/1b clinical trial at the 2025 American Society of Clinical Oncology (ASCO) Annual Meeting. Bicara is also enrolling in additional phase 1b expansion cohorts to evaluate ficerafusp alfa in 1L r/m HNSCC.

At the American Association for Cancer Research (AACR) Annual Meeting 2025, Bicara presented several datasets highlighting the therapeutic potential of ficerafusp alfa, including translational data demonstrating its effectiveness in blocking TGF-β signaling and enabling tumor penetration to modulate key mechanisms associated with drug resistance.

Bicara's lead program, ficerafusp alfa, is a bifunctional antibody being developed for head and neck squamous cell carcinoma and other solid tumor types. The company's CEO, Claire Mazumdar, Ph.D., MBA, expressed confidence in the potential of the data to demonstrate differentiated depth and durability of response driven by the TGF-β arm of ficerafusp alfa.

In light of these financial results and ongoing developments, Bicara Therapeutics appears to be strategically positioned to advance its clinical programs and maintain its strong momentum in the cancer therapeutics space. Following these announcements, the company's shares moved 9.41%, and are now trading at a price of $14.19. For the full picture, make sure to review Bicara Therapeutics's 8-K report.

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