Sionna Therapeutics Reports Positive Phase 1 Data

By Bobby Samwell • Monday, August 11 15:51 • Permanent Link

Sionna Therapeutics, Inc. (NASDAQ: SION), a clinical-stage biopharmaceutical company focused on developing treatments for cystic fibrosis (CF), has reported its financial results for the second quarter of 2025. The company announced positive phase 1 data for its first-in-class nucleotide binding domain 1 (NBD1) stabilizers, Sion-719 and Sion-451.

In terms of financial performance, the company's research and development expenses increased to $15.4 million for the second quarter of 2025, up from $8.2 million for the same period in 2024. General and administrative expenses also rose to $6.5 million for the second quarter of 2025 compared to $3.1 million for the second quarter of 2024. The net loss for the second quarter of 2025 was reported at $18.1 million, compared to a net loss of $8.6 million for the same period in 2024.

Sionna maintained a strong cash position, with approximately $337.3 million in cash and cash equivalents as of June 30, 2025, which is expected to fund operations into 2028.

In terms of pipeline updates, Sionna is on track to progress Sion-719 into a proof-of-concept trial in the second half of 2025, with topline data anticipated in mid-2026. Additionally, the company is advancing a phase 1 healthy volunteer trial to evaluate Sion-451 in combination with proprietary dual combinations, with topline data also expected in mid-2026.

Sionna also presented preclinical data at the European Cystic Fibrosis Society's 48th annual conference, demonstrating that its NBD1 stabilizers, in dual combinations with proprietary complementary modulators, enable full correction of F508del-CFTR in CF models.

Today the company's shares have moved 5.83% to a price of $18.70. Check out the company's full 8-K submission here.

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